Narcolepsy causes and mechanism

With narcolepsy?

Who is overcome by sleepiness in important scenes strong is what counts! Disease could be lurking, rather than just sleepiness

Attacked by drowsiness and should be asleep at night during the day strong State is called “supercooled sleep deprivation syndrome”. Also just sleep in sleep deprivation over the shortage will occur such as insomnia and sleep apnea may affected also. Typical disease of excessive sleep deprivation syndrome, narcolepsy.

Features of narcolepsy is long-term, unbearable daytime sleepiness happen every day and body force may leave suddenly when the surprised, laugh, emotional paralysis occurs. May be it misunderstood both symptoms occur in schools and companies marveled from other people, and also.

Racial difference in prevalence of narcolepsy is, relatively few in the West, is approximately n/a people in percentage of n/a people Japan, patients there are n/a people nationwide. Is not a rare disease. ‘Mahjong hourouki’ famous fleamarkets asagaya Tanaka Tetsuya (irokawa Takeshi Univ.) and I also was fighting this narcolepsy and is known.

Symptoms begins puberty n/a years focusing on often and no gender difference frequency. Who has the same disease in the family are 4.3% to 7.4% of the patients who are the majority of other people alone, we develop.

Causes of narcolepsy

other only is to onset identical twins but thing also . also unilaterally to develop even identical twins. Genes are not the only cause is

The cause of narcolepsy is yet to be determined. Commentary about what is currently considered as the cause.

System specific genes and stress
Also blood leukocytes involved said. I point and say, blood type common to ABO and Rh type, these are the red blood cells. White blood cells also has a different blood type, say ” ( HLA ) human leukocyte antigens”. Many hereditary diseases and related research in blood type of white blood cell.

In the Japanese narcolepsy patients are known to have a certain type of almost everyone in HLA. However, not 12 to 38% of the entire Japanese, so the same type of HLA has this gene must be narcolepsy.

Will therapy develops narcolepsy in identical twins if the gene only to get sick with the same gene. Chance actually develops both twins however, about 30%. In a recent study, has been known to become easier to develop narcolepsy in people with a genetic predisposition to join a stress can.

Lack of Orexin-A protein by??
Low concentration of Orexin A in about 90% of the typical narcolepsy involve emotional paralysis, patients, one of the proteins in the cerebrospinal fluid is known. Orexin-is in brain may deep relationship arousal system neural network and neural network to control the muscles working.

From this for low concentration of Orexin narcolepsy, Orexin-working is failure believed not the cause sleep seizures and paralysis, emotional and.

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