Of collagen and hyaluronic acid injection little nip and tuck

This time, recently the collagen and hyaluronic acid fill in the midst of petite fairing of popularity are picked up.
When generally, the foreign material is filled, the result of the immune reaction, there is a possibility the inflammation occurring.However, as for the collagen and hyaluronic acid, with the shade of the constitution component of the place of the immune reaction, it is not recognized as the foreign material.Depending, filling, because the immune reaction does not occur, safety is high, is.
The place of this immune reaction is called “between quality”.The fact that “quality in the between” is formed is, “the matrix outside the cell”.It is the case that “the matrix outside this cell” becomes the acceptance place of the collagen and hyaluronic acid, but because there is an enzyme which disassembles that, the effect of those fills does not endure.
It becomes the article whose terminology for explaining is many, but please associate to end.

The skin, from above, the epidermis, is three layer system of the cutis and subcutaneous organization.
Among those, the region which fills the collagen and hyaluronic acid is the part of organization under the skin the cutis ~.And, you expressed some time ago, but the place where the inflammation occurs, it calls between the cell and the cell “between quality”.
In the cutis, between quality, there is a blood vessel & a nerve and a sweat gland fat gland hairy root of the attachment vessel of the skin.
The fact that quality at this time is formed, is the matrix outside the cell.
components of the extracellular matrix, adhesion proteins such as collagen-proteoglycan is-.

to explain a little more in detail…
collagen fibers, is a protein secreted by fibroblasts.
the synthesis of collagen fibers, vitaminCis required.
water-holding proteoglycans are components. carbohydrate majority, is the protein part.
hyaluronic acid is one of the constituents of the proteoglycan.
adhesive proteins, as the name, cells and, is a protein that serves as a glue to attach cells and extracellular matrix. in the blood (in plasma) from the same protein in the blood because there is also, we know that the stain was.

(with the structure of collagen fibrils? )

since the amount of that part of the dermis and collagen injected into the, will be the skin is stretched. as a result, wrinkles will be reduced. let’s take a look at its structure in.

collagen, molecular structure looks complicated at first glance. if you look closely, sequence of amino acids glycine-X-Y-glycine-X-Y-glycine-X-Y-structure is simple repetition of. X-Y-is part of a certain trend, but there, there is no strict limit.
collagen, fibroblasts produce a protein, is attached to the amino acid glycoprotein that some sugar is the nature of the common variety of protein secreted into the extracellular.
as a result, X-Y-the diversity of diversity of amino acids and sugar chain portion of the, collagen fibers is extremely heterogeneous glycoprotein with a variety of sugar to protein.

collagen injection is not used for human origin, is usually derived from bovine.
originally, immune system should recognize as foreign because biologically heterogeneous.
if the protein collagen is however very non-uniform (glycoprotein) so, more than the difference between the human and bovine, yuanbecause of their high diversity of, likely to be recognized as foreign is nil.

on the next page
describes the hyaluronic acid.
reason and duration of effect is shorter when the injection, this also includes a brief description if swallowed if painted. (hyaluronic acid2types of long chains of sugar)

hyaluronic acid, is famous as a moisturizing ingredient. the epidermis also contain a hyaluronic acid. in the dermis of the injection location, it is one of the constituents of the extracellular matrix proteoglycans. if the injected, result that holds the water many times that amount at the site of injection, stretched skin dermis to increase the apparent, wrinkles will be reduced.

hyaluronic acid is a glycosaminoglycan (amino sugar+uronic acid) is a kind of.
2type (acetyl glucosamine+glucuronic acid) is a long chain of monosaccharides has led to alternating.
since there is no antigenic structure is simple, even if there is no injection of impurities in high purity, that does not provoke an immune response.
consider a linear thing, but rather chain and, please imagine a chain that curled.
this structure that is curled, you can hold a large amount of water around.
hyaluronic acid for its, as with other glycosaminoglycans, this material is very high water-holding capacity.

proteoglycans, core protein to bind to hyaluronic acid mandrel, it surrounds the around it, hyaluronic acid and glycosaminoglycan is another.

(sustained at the time of collagen, hyaluronic acid was injected into the? )

if the injection is not effective long lasting unfortunately. but because there is an enzyme that breaks down, this section describes the enzyme.

the enzyme, the matrix metalloproteinase naples (MMP) this is called.
MMPis, generic name of the group in a series of enzymes to break the extracellular matrix, 20there are more than. collagen and hyaluronic acid that is a constituent of the extracellular matrix is as already mentioned. actual, more than oneMMPdisassemble the collagen is.

hyaluronic acid will absorb a large amount of water in the local. changes or contour of the face is raised to its local, wrinkles will be reduced. hyaluronic acid, as the material of the proteoglycan, is used. then, more than oneMMPbreaks down the collagen and proteoglycan is similar to.

in the dermis of healthy skin, MMPbecause the function is of course, effect does not last so long.

(collagen, hyaluronic acid is null only for the effects of moisturizing! )

collagen also ceramide it is recommended.

(i drink? )

collagen, because it is protein, proteolytic enzymes of the digestive juices will drink and degradation. hyaluronic acid is decomposed, become a short sugar, will be eventually be absorbed as amino acid.

that is…
collagen, the extracellular matrix of the dermis of both hyaluronic acid, it was kept in the form of the structure is true that it does not reach.