HIVthe main type of drug and effects of growth mechanisms and

Before commenting concerning the medicine of HIV, first, HIV how being infected to the immunity cell (CD4 positive lymphocyte) mainly, you explain whether it keeps multiplying.

Feature of the virus, HIV

HIV is the companion of uisuru which is called the “retro-virus”.The virus cannot duplicate and/or synthesize the protein with just that RNA (the heredity substance, = ribonucleic acid) it is not possible therefore to increase.Being infected to the cell which can increase by your, that in the cell where you are infected, it has making itself RNA and the necessary protein, multiplying keeps.

DNA has done double helical structure.
* The gene, it means the thing of the part which had the information of heredity even in DNA

Already when you explain a little specially, as for HIV the virus which consists of RNA.Entering into the immunity cell, in order for you to increase by your, it is necessary to become DNA.

Because of that, it had the information of the heredity of HIV in the structure whose igaiga of HIV is round “RNA” and, “the reversal copying enzyme” because it becomes DNA from RNA, “integuraze” in order to enter into DNA which is the nucleus immunity and, three substances have entered mainly.Concerning the condition of HIV, this article viewing.

HIVhow the proliferation of immune cells is infected with the

then, thatHIVintroducing the process of going to the proliferation of immune cells is infected with the.

1. invasion of immune cells
HIVto adhere to the surface of immune cells is. and, in immune cells, HIVlocated in theRNAreverse transcriptase and, is pushed to the integrase.

2. HIVofDNAsynthesis
caught in the immune cells of theRNAis, using the reverse transcriptase, HIVofDNAmake a.
RNAis, 1should look something like this string of heavy. there, make a string of another one corresponding to the string it with the material in the immune cells, 2the state of the double helix. itDNAis an image of.

3. DNAbuilt-in
made in immune cellsHIVofDNAis, you get inside the nucleus of immune cells. of immune cells in the nucleus itselfDNAthere are, thatDNAin the, HIVofDNAwill be incorporated (provirus) . thatDNAmaterial is necessary to incorporate the integrase.

4. HIVparts of (RNA, protein, such as enzymes) synthesis of
HIVofDNAis, protein in the nucleus or from their ownRNAthe instruction to make a. then in the immune cells, HIVofRNAand protein, such as reverse transcriptase will be created.
for details, of immune cellsRNAby polymerasemRNAis transferred to the, mRNAis translated, HIVsuch as proteins and enzymes will continue to be made.

5. HIVescape from the immune cells mature and (release into the blood stream)
HIVofRNAand protein, been assembled and a new enzymeHIVyou can lump of. its mass and structure of the first such igaiga, we will move beyond the immune cells. when immune cells to burst from the, by proteolytic enzyme called protease, the first time to cut the proteinHIVyou can jump out to mature is.

(since we ran out to receive a part of the cell membrane of immune cells, will take over the structure of the membrane, similar to immune cells, HIVdevelopment of drugs that attack to recognize the structure of the film is so difficult. )

the next page, HIVhere are the types and characteristics of the drug.

HIVtype of drug

HIVmedicine is, as described aboveHIVinfected with the immune cells is, process of growth continue to1~5by inhibiting the flow of, shows the effect. ia, 4there is no medicine (normal protein synthesis in normal cells, RNAfor example, would also inhibit synthesis)

below, HIVgeneric name the type of, abbreviation, product name, selling company name, date of approval (standards date of approval of the first difference specification) will introduce in the order of.

entry inhibitor (CCR5inhibitor)
to immune cellsHIVmedicine to reduce the intrusion is. (previous page1acting on the)
maraviroc (MVC) , st. shieru re-, vu~ivu health care (2008/12)

reverse transcriptase inhibitors
HIVofRNAfrom, DNAdrug is made and to inhibit. NRTIandNNRTIof2can be divided into type. (2acting on the)

-nucleoside reverse transcriptase inhibitors (NRTI)
zidovudine- (AZT, ZDV) , retorobiru, vu~ivu health care (1987/10)
-didanosine (ddl) , vai indexEC, bristol-myers (2001/3)
-lamivudine (3TC) , epibiru, vu~ivu health care (1997/2)
· sanirubujin (d4T) , bristol-myers (1997/7)
-ATZ/3CT, combivir (combination tablets) , vu~ivu health care (1999/6)
abacavir- (ABC) , zaiajen, vu~ivu health care (1999/9)
-ABC/3TC, epujikomu (combination tablets) , vu~ivu health care (2005/1)
· tenofovir (TDF) , billiards, japan tobacco, torii pharmaceutical co., ltd., (2004/3)
-emtricitabine (FTC) , emutoriba (capsule) , japan tobacco, torii pharmaceutical co., ltd., (2005/3)
-TDF/FTC, tsurubada (combination tablets) , japan tobacco, torii pharmaceutical co., ltd., (2005/3)

· non-nucleoside reverse transcriptase inhibitors (NNRTI)
-nevirapine (NVP) , biramyun, nippon boehringer ingelheim co., ltd. (1998/11)
– efavirenz (EFV) , stock phosphorus, MSD (1999/9)
bill de la gin-hydrochloric acid mesyl (DLV) , les scripter, daiichi sankyo co., ltd. pfizer (20000/2)
· etorabirin (ETR) , in terence, janssen pharmaceutical kk (2008/12)

integrase inhibitor
HIVofDNAis, of immune cellsDNAbeing built into the drug to inhibit. (3acting on the)
lartet potassium-ground building (RAL) , isentress, MSD (2008/6)

protease inhibitor (PI)
HIVdrugs that inhibit the immune cells leave the maturation and. (5acting on the)
-indinavir (IDV) , kurikishiban, MSD (1997/3)
-saquinavir (SQV) , inbiraze, chugai pharmaceutical co., ltd. (1997/9)
-ritonavir (RTV) , nobia, abbott japan co., ltd. (1999/9)
nelfinavir- (NFV) , viracept, japan tobacco, torii pharmaceutical co., ltd., (1998/3)
lopinavir-ritonavir-formulation (LPV/RTV) , kaletra, abbott japan co., ltd. (2009/9)
atazanavir- (ATV) , reiatattsu, bristol-myers (2003/12)
fosamprenavir- (FPV) , rekushivu~a, vu~ivu health care (2005/1)
· darunabiru (DRV) , purijisuta (300mglock) , pre-register naive (400mglock) , janssen pharmaceutical kk (2007/11, 2009/8)

over, 2010years11drug is being used now been approved in japan in mon. about how to use the medicine and side effects of each, HIVside effects of drugs and precautions please refer to.

reference materials

• HIVinfection guidance of treatment of14version, HIVtechnical committee on infection treatment
• MSDhome page for medical personnel, infection page

Incoming search terms:

• epujikomu (1)